FP390A MATHEMATICAL MODEL OF BONE REMODELING IN PATIENTS WITH UREMIA AND METABOLIC BONE DISEASES

Clinical Value of the Biochemical Markers of Bone Remodeling in the Assessment of Bone Metabolic Diseases

In clinical practice, low bone mineral densi ty (BMD) and, therefore, scarcity of bone mineral is identified and quantified by dual energy X-ray absorptio-metry (DXA) (1). However, BMD predicts only 66Ê74% of variance of the bone strength (2), and many individuals with normal areal BMD suffer fractures (3). It is well recognized that other aspects of bone composition and structure may contribut...

The Cellular Dynamics of Bone Remodeling: A Mathematical Model

The mechanical properties of vertebrate bone are largely determined by a process which involves the complex interplay of three different cell types. This process is called bone remodeling, and occurs asynchronously at multiple sites in the mature skeleton. The cells involved are bone resorbing osteoclasts, bone matrix producing osteoblasts and mechanosensing osteocytes. These cells communicate ...

Metabolic bone diseases: an overview.

Bone magnesium pools in uremia.

Bone magnesium pools were studied in vitro in bone specimens obtained from control subjects, from patients with chronic renal failure before and after renal transplantation, and in a patient with chronic hypomagnesemia. 30% of bone magnesium is in a surface limited pool present either within the hydration shell or else on the crystal surface. The larger fraction of bone magnesium was shown not ...

[Histologic diagnosis of metabolic bone diseases: bone histomorphometry].

Histomorphometry or quantitative histology is the analysis on histologic sections of bone resorption parameters, formation and structure. It is the only technique that allows a dynamic evaluation of the activity of bone modelling after labelling with tetracycline. Moreover, the new measurement procedures through the use of the computer allow an assessment of bone microarchitecture too. Histomor...